Cardarine (GW-501516) Review

What is GW-501516? Does it have any side effects? What effects can you expect from using this product? What should you know before buying it? You will find answers to these and other questions in the article below.

What is Cardarine?

sarm GW-501516 capsulesCardarine, also known as GW-501516 or Endurobol, is a substance created in the 1990s by two pharmaceutical corporations: GlaxoSmithKline and Ligand Pharmaceuticals. Its main goal is to prevent diseases related to heart disease and metabolic syndrome. Thanks to its incredible ability to accelerate metabolism and burn fat tissue, it quickly gained popularity among athletes. 

Due to its selective action, GW-501516 is often mistakenly classified as SARM (Selective Androgen Receptor Modulators). In fact, it is a PPARδ receptor agonist. 

Activation of the PPAR-delta pathway causes a sudden increase in endurance and acceleration of metabolism while lowering blood lipid levels. 

Cardarine Benefits

Although GW-501516 is mainly known to athletes as an excellent reduction supplement, it also has a number of other advantages:

  • Accelerates fat burning
    For many people the most crucial feature of Cardarine. The action of GW-501516, however, differs significantly from an average cutting supplement, which usually contains only thermogenic substances.  By acting on the pathway PPAR-delta, it activates a large number of genes responsible for fat burning. It also changes the way our body reacts to meals that have a high glycemic index.
    “Here we report that mRNA expression of PPARδ was increased in the skeletal muscle from exercise responders, which may provide a mechanism for the positive changes in the lipid profile and insulin sensitivity in this group. PPARδ functions as a lipid sensor that coordinates changes in gene expression to promote oxidative metabolism in skeletal muscle [30]. Recent evidence from our laboratory shows PPARδ agonists mimic an exercise response by promoting gene regulatory responses in cultured human skeletal muscle”.
  • Increases strength and strength
    Increased strength is associated with the activation of the PPARδ path. It changes the way our body metabolises fats and glucose, thus ensuring greater endurance. This has been confirmed by the opinions of both GW-501516 users and clinical trials. In one of these studies, mice were subjected to severe endurance training.After using Cardarine, they were able to cover a much longer distance than in the control study and showed increased tolerance to chronic exercise.
    In another study, this time on humans, the participants experienced a significant increase in strength. However, at this stage, we cannot say whether this is due to the anabolic properties of the substance or solely to more efficient energy management by the body.
    The fact that GW-501516 is on the WADA list (this means that professionals can not use it) gives a picture of how strong this substance is. 
  • Protects the brain
    One animal study indicates that GW-501516 can protect the brain at times of hypoxia. In addition, substances which affect PPAR are known for their ability to accelerate the development of nerve cells. This suggests that Cardarine as a subgroup of PPAR (PPAR-delta) may also have a similar effect.
    Furthermore, in one study on rat brain cells, Cardarine reduced inflammation of TNF-alpha cells. 
  • Protects the heart and circulatory system
  • Endurobol can have a positive impact on the functioning of the circulatory system. Research on mice shows that low doses of GW1516 prevented arterial damage. Unfortunately, the increase in dose did not change the magnitude of the patronizing effect. Also, no human studies have been conducted to date to check this ability.
    However, it is not the only pro-health effect. Evidence suggests that Cardarine can change the way our entire circulatory system functions. It reduces oxidation damage and increases the amount of nitric oxide present in the blood, thus relaxing the vessels and preventing atherosclerosis.
    We also know that it accelerates the formation of new blood vessels in the heart. This is excellent news for people with heart disease. 
  • Helps to fight obesity
    In another study we managed to discover, Cardarine was given to 6 obese people in a double-blind, random and controlled trial. It helped to cure the symptoms of metabolic syndrome in all subjects without causing any side effects.
    The participants took a maximum of 10 mg per day for only two weeks. After such a short period of time, positive changes in liver steatosis, insulin sensitivity and lipid levels were already visible. Therefore, we can conclude that GW-501516 is a great supplement to fight insulin resistance caused by obesity and chronic inflammation.
    In yet another study, conducted this time on obese mice, Cardarine reduced the risk of heart disease by lowering LDL cholesterol, triglycerides and insulin levels. It also reduced the overproduction of glucose by the liver. This means that Endurobol can be a good supplement for people with type 2 diabetes (if it has the same effect in humans).
  • Reduces inflammation
    By activating the PPAR-delta pathway, Cardarine decreased inflammation of the liver during animal studies. It was even able to stop the development of inflammation at the DNA level!
    Applied topically on the skin, it reduced inflammation in mice and accelerated wound healing. So far, scientists have proven that it reduces the production of pro-inflammatory molecules such as NFκB, IL-6, TNF-alpha, and MCP-1.
  • Reduces the risk of kidney disease
    In the study mentioned above, Cardarine reduced the expansion of genes associated with kidney disease, thus reducing the likelihood of their occurrence. 
  • Protects the liver
    That’s the last of the benefits we know. As you can easily guess, GW-501516 also affects liver function since it is the main organ responsible for fat metabolism. Endurobol reduces blood sugar levels forcing the liver to take energy from fats instead of glucose. It also has a protective effect against the effects of a diet rich in fructose (avoiding fatty liver if you consume >50g of fructose a day). In one mice study, endurobol also reduced the risk of liver damage by destroying degenerated cells.

Potential Cardarine Side Effects

There are not many studies on Cardarine side effects, especially on humans. Users also very rarely complain about any side effects. However, we have found studies that indicate that this substance may also potentially have side effects. 

Firstly, as mentioned earlier, GW-501516 has the ability to destroy degenerated liver cells. While this is usually a positive thing, it is definitely harmful for people with liver disease. In such people, whose liver has problems with proper work without additional means, Endurobol, by destroying some cells, aggravates these problems. This is why GSK has discontinued its marketing of the drug. 

The other potential side effect is also related to the benefit mentioned above. Due to the acceleration of the expansion of some cells, the risk of their mutation is also increasing, thus increasing the risk of cancer.

Please note that the above-mentioned side effects were observed during the studies on mice. None of these side effects has been observed in human clinical trials – however, these studies were too short for such effects to be observed. 

Results from using Cardarine

You can expect a significant improvement in endurance during cardio training and the loss of 4-5kg of fat in 8 weeks by using 20mg per day. GW-501516 runners improve their 5K times by an average of 45s after just two weeks of use. The benefits of fat loss are usually visible in 3-4 weeks, so it is advisable to buy a dose for at least ten weeks.

My Personal Experience with GW-501516

I have had the opportunity to use Cardarine only once – in combination with Ostarin, and I will certainly use it again. I can only talk about this combination in superlatives. Despite using both substances in quite high doses for 10 weeks, I did not experience any side effects. Throughout the whole period of cutting I felt great. I also found the results very satisfying. Before the cycle, my bf level was around 13%, after 10 weeks I reached ~8%. 

The first thing I noticed as early as the first week was a significant increase in endurance during cardio training. It was a very nice bonus for me (yes, I know for some that’s the main reason for using Cardarine), given that I was usually cutting using Trenbolone. 

Before and after GW-501516

Cardarine Dosage

During clinical trials, doses ranging from 2.5mg to 10mg per day were administered. 

Athletes usually take 10mg to 20mg daily for 6-12 weeks. If you decide on a dose of 20 mg, it should be divided into two servings – 10 mg in the morning and 10 mg in the evening, as the half-life of GW-501516 is about 16h. 

Best GW-501516 Cycles

If you only want to improve your endurance, 20mg Cardarine solo is enough. This type of cycle is also suitable for a slight reduction. You should be able to lose a few pounds of fat in two months without any problems.

If you need to shed more weight, I recommend combining it with Ostarin. These substances blend perfectly with each other giving phenomenal effects.

Best place to buy Cardarine

Unfortunately, due to the high prices of SARMs in the wholesale trade, many vendors sell low quality products. Most products available on the market have less substance than declared. And actually it is a situation in which we are often lucky … Adding oral steroids or prohormones is just as popular. For this reason, we should always buy SARMs from reliable sources that have a certificate of analysis issued by an external laboratory for each batch of the product. 

Stores that we have checked and recommended:

Proven Peptides

proven peptides logo

Currently the most popular SARM seller in the world. They offer high-quality products. You can quickly get a certificate of analysis for each of their products. They offer SARMs only in the form of solutions. Each bottle has a pipette and information on how many drops corresponds to a ml of solution. They are one of the few to offer telephone contact so that you can resolve any doubts within minutes. They also offer the loyalty program “Peptide Points” where you can collect points that give you discounts on subsequent orders. Some people have reported problems with damaged bottles, but I believe this is the fault of the couriers rather than the company itself. Personally, I have never had any issues with them. Shipping from the USA.
Click here to check price


Chemyo logo

They have been present on the market for about two years. Quickly gained popularity thanks to affordable prices and good quality products. Like Proven Peptides, they offer SARMs only in the form of solutions. Unfortunately, there is no measuring system attached to the bottle, so you have to buy a syringe (you can buy it on their website) or other device that allows you to measure the dose accurately. A huge advantage is the certificates of analysis placed on the website for each of the products. Shipping from the USA.
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swisschems logo

A relatively new company on the market. Like previous ones, it offers analysis certificates for each of its products. They offer not only SARMs, but also Aromatase Inhibitors and PCTs. The products are available in tablet form, which is a more convenient option for many customers. Unfortunately, their products are relatively expensive and their quality does not significantly exceed that of Proven Peptides or Chemyo. Shipping from the USA.
Click here to check price


Although it has been our favourite shop for a long time, we are forced to change our recommendation. In recent months, contact with them has become difficult, parcels are delayed, and there is a lot of negative feedback on the effectiveness of their products. I apologize to all the people who bought their products in recent months based on my recommendation. 


How to take cardarine?

Since the half-life is relatively short, it is best to divide the daily dose in half. One dose should be taken in the morning before the first meal and the other in the afternoon. If you decide to take GW once a day, it is best to do this on an empty stomach – this ensures the best absorption. 

Is cardarine legal?

At the time of writing this article, Cardarine is legal in most countries of the world, including USA However, the substance is on the WADA list, which means that it cannot be used by professionals. 

Is cardarine safe?

Current research indicates that Cardarine is a relatively harmless substance. The only potential side effects were observed in one mouse study, but in this study, massive doses were used – equivalent to approximately ~583mg GW-501516 for the average person. 

Stenabolic vs cardarine

Personally, it is difficult for me to compare the two substances because I have never used stenabolic solo. However, Cardarine is a more popular substance, so we can find more information and reviews about it. For this reason, I would prefer to choose the latter. 

Cardarine pct

GW-501516 does not cause testosterone suppression and therefore does not require PCT.